Metformin — Longevity

Why Metformin

What this treatment offers

Decades of clinical use

Metformin has been widely prescribed for decades, and your provider will review your health history, medications, and kidney function before determining whether it is appropriate.

Metabolic foundation

May help support insulin sensitivity and glucose metabolism when prescribed for appropriate patients.

Active longevity research

Metformin is being studied in aging-research initiatives, including the TAME trial framework, to better understand its potential relationship to aging biology.

Simple daily protocol

A once- or twice-daily tablet, prescribed and monitored by your provider.

How it works

Care without the waiting room

Start your assessment

A 5-minute online health questionnaire — no appointment, no waiting room.

Provider review

A licensed provider in your state reviews your history and prescribes if appropriate.

Pharmacy ships direct

Your medication ships from a licensed U.S. pharmacy in discreet packaging.

Ongoing support

Message your care team anytime. Dose adjustments and refills handled online.

FAQ

Metformin questions

Why do people take metformin for longevity?

Researchers have observed associations between metformin use and favorable health outcomes beyond diabetes, prompting formal study of its effects on aging biology. It is prescribed off-label for this purpose when a provider determines it's appropriate.

What are common side effects?

Digestive upset is most common, particularly when starting. Taking it with food and gradual dose increases usually help. Your provider will review your kidney function and health history first.

Do I need to have diabetes to qualify?

No — your provider evaluates your metabolic health, labs if available, and goals to determine whether metformin is clinically appropriate for you.

Important safety informationMetformin is available by prescription only after evaluation by a licensed provider and only if prescribed. Possible side effects may include nausea, diarrhea, stomach upset, loss of appetite, or a metallic taste. Rare but serious risks may include lactic acidosis, especially in patients with certain kidney, liver, or heart conditions. Tell your provider about all medical conditions and medications during your assessment. If this medication is compounded for you, it is prepared by a licensed pharmacy for an individual patient and is not FDA-approved; the FDA does not verify the safety, effectiveness, or quality of compounded drugs. Individual results vary. This page is educational and is not medical advice.